Nicotinamide riboside supplementation for substantially longer, healthier life

Discussion in 'Science' started by antipody, Jul 24, 2016.

  1. antipody

    antipody Member

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    I've had June's issue of Science floating around for a month now. Read it a few times, but this article is still sinking in. Quite a major discovery, with enormous potential...

    NAD[sup]+[/sup] repletion improves mitochondrial and stem cell function and enhances life span in mice


    http://sci-hub.cc/10.1126/science.aaf2693

    Human trials will be next, but I have little doubt they'll show similar results, as the mechanism shouldn't be hugely species dependent.

    In short, all our cells produce a suite of enzymes, called sirtiuns. This truly amazing class of molecular machines repair DNA, detoxify, and play other roles in metabolism and cell health, particularly, but not only in mitochondria. As we age, the "fuel", a coenzyme that these surtuins consume, called Nicotinamide adenine dinuceotide, NAD is consumed at a higher rate than ageing cells can keep up.

    The experiment was as simple as supplementing mice with Nicotinamide riboside (NR), which is converted to NAD[sup]+[/sup] apparently allowing older cells to keep the fuel required by PARP and surtuins coming, allowing the organism to resist so many of the diseases we call "ageing"...

    Just when you thought the boomers were going to die off...:shock:
     
    Last edited: Jul 24, 2016
  2. sTeeLzor

    sTeeLzor Member

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    Very interesting.
     
  3. oculi

    oculi Member

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    I used to drink an energy drink called oramin c, think it was Japanese, it had nicotinamide in it. Wonder if it is the same variety?
     
  4. RnR

    RnR Member

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    Don't forget Urolithin A...

    https://www.sciencedaily.com/releases/2016/07/160711120533.htm
     
  5. sTeeLzor

    sTeeLzor Member

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    Will it increase my midichlorian count as well?
     
  6. antipody

    antipody Member

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  7. RnR

    RnR Member

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    A little update - a small and short human trial has finished.

    https://www.sciencedaily.com/releases/2016/10/161010135418.htm
     
  8. antipody

    antipody Member

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    The evidence continues to mount...

    From October's Cell Metabolism...

    http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30482-X

    Also...

    http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30504-6

    I turned 40 this year, so put in an order for some of the good stuff. Not that I'm unhealthy by any stretch, but interested to see how I feel after taking it for a while.
     
  9. Foliage

    Foliage Member

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    Need more sources, I'm not convinced yet.
     
  10. RnR

    RnR Member

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    Any evidence that the chemical is contributing to tumour growths?
     
  11. Reins

    Reins Member

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    I might be wrong here, but surely unless you're already unhealthy/ageing severely you won't see many effects at all, right? More of a continuation of your current state, as opposed to a degradation.

    EDIT:
    This stuff is actually quite interesting. The thought of having pharmacological reversal of principal mechanisms of diseases is really, really cool. One day they will be able to identify recessive phenotypes and then apply a reversing agent so that it doesn't get passed on.
     
    Last edited: Oct 15, 2016
  12. Bold Eagle

    Bold Eagle Member

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    Last edited: Oct 15, 2016
  13. Bold Eagle

    Bold Eagle Member

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    So far it indicates increased efficiency in what is in place.

    It's called google scholar - only so much can be spoon fed -
    https://scholar.google.com.au/scholar?hl=en&q=+Nicotinamide+riboside&btnG=&as_sdt=1,5&as_sdtp=

    Frankly it is not hard to find a "lot" of evidence that "Nicotinamide riboside" have a significant impact on humans....

    This is of interest:
    http://www.annualreviews.org/doi/abs/10.1146/annurev.nutr.28.061807.155443
     
  14. Foliage

    Foliage Member

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  15. antipody

    antipody Member

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    My ex-wife introduced me on to Berocca in my late 30s, mostly for a post party night recovery.

    It's amazing stuff and, in my entirely anecdotal, n=1 study, I like the way it makes me feel. It seems to make me feel a bit more energetic and alert.

    Berocca has a lot of B3 in it and I wouldn't be surprised if NAD repletion and enhancement of PARP and surtuin activity is responsible for that.

    At the age of 40, I think I can qualify as "ageing". I don't currently suffer from any age related diseases, but the purpose of taking such a supplement now is to ensure the next few decades, when the decline begins, are as healthy as possible.
     
    Last edited: Oct 16, 2016
  16. Foliage

    Foliage Member

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    Placebo effect at its best. Your body is the most biased thing ever, self experimentation is useless for that reason.

    Only way to know for sure is with a double blind study across a large population.

    I wouldn't trust the supplement yet. For years everyone went on about antioxidants when ironically they make you weaker as shown by the latest meta analysis.
     
  17. RnR

    RnR Member

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    To be honest, I think the best way to get similar effects is to work with your DNA and adopt a fasting protocol.

    While you are at it, adopt a meditation protocol as well.
     
  18. antipody

    antipody Member

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    Which antioxidants, which oxidative stresses and which meta analysis are you talking about?

    Are you telling me blueberries and kale aren't good for me?
     
  19. Foliage

    Foliage Member

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    Chronic fasting is the only thing that has been categorically proven to prolong your life, and by quite a large margin.
     
  20. antipody

    antipody Member

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    In today's Science Translational Medicine update:

    http://stm.sciencemag.org/content/8...stm_2016-10-19&et_rid=103986717&et_cid=909808

     

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