http://www.thebulletin.org/web-edition/columnists/laura-h-kahn/diy-biology I've got a friend with a PCR machine bought off ebay, which she uses to sex her chickens, by amplifying DNA using promers which recognise segments of the sex hormoneschromosomes, and running a gel. The hardware to do biotech stuff is now moving towards pricing which makes it accessible to an enthusiastic amateur. We're talking a similar cost to buying and maintaining a rally car or similar. The knowledge is more difficult to gather, but there's a good set of tools available for those with some university biochemistry, or equivalent. It's going to be a wild ride over the next few decades. I have an idea that when I retire I'd like to tinker with genetically modifying orchids.