Nicotinamide riboside supplementation for substantially longer, healthier life

Discussion in 'Science' started by antipody, Jul 24, 2016.

  1. Bold Eagle

    Bold Eagle Member

    Joined:
    Jun 28, 2008
    Messages:
    6,714
    Location:
    Brisbane
    Saw something interesting mentioned today on ABC with human trials intended in a few months.

    DNA repair discovery could lead to drugs to reverse ageing, fight cancer and help space travel

    Critical step in DNA repair, cellular aging pinpointed
     
  2. «¥» Plump-DJ®

    «¥» Plump-DJ® Member

    Joined:
    May 11, 2002
    Messages:
    265
    Location:
    Perth
    Just my 2c.

    My only source here is Michael Mosley and his 5:2 diet book and his series on BBC; Horizon. From memory, what we know is that people who fast or have calorie restricted diets produce less IGF (Insulin Growth Factor) which is associated with less cancer and cell damage in a person's body. The theory is your body spends less time replicating and creating new cells and more time repairing what it has.
     
  3. «¥» Plump-DJ®

    «¥» Plump-DJ® Member

    Joined:
    May 11, 2002
    Messages:
    265
    Location:
    Perth
    Actually for anyone who has ever looked at the 5:2 diet and it's overall benefits to your health.. this looks interesting :

    Fasting Mimicking Diet (FMD
    http://www.telegraph.co.uk/wellbeing/diet/why-weve-all-been-doing-the-fast-diet-wrong/

    In his study, reported this week in the journal Cell Metabolism, old mice placed on cycles of a four-day low-calorie diet had reduced visceral belly fat, and increased numbers of progenitor and stem cells in several organs — including the brain, where neural regeneration was boosted, as was memory."

    "...Decreasing meal frequency is pretty painless and by reducing meal frequency we naturally reduce inflammation (the hallmark of modern chronic disease) in our bodies.’’
     
    Last edited: Mar 24, 2017
  4. OP
    OP
    antipody

    antipody Member

    Joined:
    Jul 28, 2001
    Messages:
    4,993
    Location:
    Small World
    There link to a talk earlier in this thread, about the interaction between metabolism, diet and cancer. Well worth listening to.

    Another study in last week's Science update suggests pancreatic function is improved by fasting...


    http://science.sciencemag.org/conte...ci_2017-03-23&et_rid=103986717&et_cid=1233308

     
  5. RnR

    RnR Member

    Joined:
    Oct 9, 2002
    Messages:
    10,861
    Location:
    Brisbane
    NAD hits the news again...

    http://www.abc.net.au/news/2017-08-...prevent-miscarriage-and-birth-defects/8785566
     
  6. syahrr01

    syahrr01 Member

    Joined:
    Jan 15, 2005
    Messages:
    1,290
    Location:
    Padbury, WA 6025
    There's different forms of Vitamin B3 supplements in the marketplace, including: NR, niacinamide, niacin and inositol hexaniacinate. It's unclear to me which forms is attributable to benefit for which study.
     
  7. OP
    OP
    antipody

    antipody Member

    Joined:
    Jul 28, 2001
    Messages:
    4,993
    Location:
    Small World
    My understanding is that they all convert to NAD+, which is the key energy carrier and conenzyme for DNA repair, so it shouldn't matter too much which form you take. However, the holder of the NR patent disagrees...
    https://seekingalpha.com/article/4040764-chromadex-response-claim-niagen-just-expensive-vitamin-b3

    One thing to keep in mind is that Niacin can be toxic at high doses. I don't think this is the case with NR.

    More on the Victor Chang Institute and birth defect study here:

    http://www.sciencemag.org/news/2017...ly_2017-08-11&et_rid=103986717&et_cid=1487863

    Fascinating...
     
    Last edited: Aug 17, 2017
  8. OP
    OP
    antipody

    antipody Member

    Joined:
    Jul 28, 2001
    Messages:
    4,993
    Location:
    Small World
    http://www.sciencedirect.com/science/article/pii/S1550413116302443

    https://www.nature.com/nrm/journal/v17/n11/full/nrm.2016.93.html

     
  9. glimmerman

    glimmerman Member

    Joined:
    Nov 3, 2005
    Messages:
    2,198
    Location:
    Perth
    I've been seeing a lot of mentions of this recently... keeping an eye on it for obvious reasons.
     
  10. RnR

    RnR Member

    Joined:
    Oct 9, 2002
    Messages:
    10,861
    Location:
    Brisbane

Share This Page