I've got a ThreadRipper system that's currently set up with 4 x 16Gb RAM (I need as much RAM as I can get/afford). At the time I bought it, it was 2 x two packs, so I was running in dual channel mode. One of the sticks has died, so I'm now down to 48Gb is single channel mode. I'm going to run some memory tests to see if any of the remaining ones are suspect as well, but for now, let's assume they are ok. RAM: G.Skill 32GB (2x 16GB) F4-3600C17D-32GTZR DDR4 3600Mhz Trident Z RGB. Motherboard (has 8 RAM slots, A1, A2 ... D1, D2): AsRock Fatal1ty X399 Professional Gaming Motherboard AMD Ryzen Threadripper TR4 I'd like to get back to 64Gb+ so I wondering what options I've got. What am I losing between Dual channel and Single Channel? Can I add 32Gb stick(s) to the system and mix with the current 16Gb sticks? e.g. 2x16Gb + 2x32Gb? What if the RAM speeds don't match? Other suggestions?