Im not a modder, (though I am getting vicous temptations from a slimline DVD player and the spare $15 Matx case that lays next to my bed). But I would think if you took into account the motherboard manufacturers specifications/recommendations, watched out for potential shortouts - you definately could. Tearing a case apart and putting it back together seems like a fair bit of effort. There are plenty of simple and easy ideas around the place. All depends on your means, patience and requirements I guess. Check examples at http://www.mini-itx.com/ The real question is how ghetto will you go?