The enormous Virtualisation help thread

From my experience combining LookingGlass and passing through a USB controller is a bloody elegant way of being able to have a dedicated mouse to a VM and being able to use your 'normal' mouse for a second OS - for a time I was playing EVE online like this. Naturally you'd often move your mouse all the way over to do things but sometimes this would be a burden and having a second mouse where it needed to be was more comfortable.