We use dual screen with one application using 1 screen, and the other screen for everything else including the Desktop. Application 1 requires a Macro Keyboard which sends out CTRL-SHIFT-1 (and 2, 3, 4 etc) to it. These cannot be changed. Unfortunately Windows' Desktop OS built in hotkey for CTRL-SHIFT-1 (and 2, 3, 4) happens to be a shortcut to change the desktop icon sizes to extremely large etc. Go on, try it. Click on your desktop and press CTRL-SHIFT-1 How can I either disable these hotkeys when its on the desktop? And still have the Application 1 working with them obviously? Or if I can re-assign them to change active application window that will be even better. Please note, these ARE NOT application hotkeys, they are Windows OS built in. Thanks!